Infections caused by Gram-negative bacterial pathogens are becoming increasingly difficult to treat due to resistance to current antibacterial drugs and there are few new, effective compounds in development that address these antibiotic-resistant strains. There is an urgent need to identify new antimicrobial drugs that will help circumvent the current drug resistance crisis. Bacterial pathogens often develop resistance to antibiotic drugs that target bacterial growth or viability. However this paper provides evidence that a strategy to specifically target virulence pathways, non-essential for growth, could open avenues for new therapeutic means and potentially limit selection for resistance. "Virulence targeted anti-infective drug development programs have the potential to be paradigm changing in the treatment of serious infections," said Tom Parr, Ph.D., Chief Scientific Officer at Spero. "We are delighted to be working with Dr. Rahme, a leader in the field, and congratulate her on the publication of this important work." "The MVfR pathway has an important role in acute virulence and in the persistence of serious bacterial infections," said Laurence Rahme, Ph.D., Scientific Founder and Advisor at Spero. "Our work supports the idea that modulators of this pathway can have a profound therapeutic effect and I am excited to collaborate with Spero to bring MvfR inhibitors into further clinical development in an effort to address this urgent public health issue." The paper will be available on the News page of the Spero website (www.sperotherapeutics.com/):
"The MVfR pathway has an important role in acute virulence and in the persistence of serious bacterial infections"
- "Identification of Anti-Virulence Compounds that Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity" authored by Spero scientific advisor and company co-founder Laurence Rahme and colleagues Melissa Starkey, Francois Lepine, Damien Maura, Arunava Bandyopadhaya, Biljana Lesic, Jianxin He, Tomoe Kitao, Valeria Righi, Sylvain Milot, Aria Tzika.
Ankit Mahadevia, M.D., 617-588-2600
Venture Partner at Atlas Ventures
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Maureen L. Suda, 585-387-9248