Active Portfolio - USA

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Aileron Therapeutics (USA) is developing a revolutionary class of drugs called Stapled Peptides that represent the first general solution, or "scaffold" for modulating intracellular protein-protein interactions that are critical control points to nearly all functions of a cell.
http://www.aileronrx.com

Alios BioPharma (USA) is developing novel medicines that treat diseases in virology by activating pathways in the innate immune system.
http://www.aliosbiopharma.com/

Anaphore (USA) is developing a new class of protein therapeutics to address significant unmet medical needs for patients with serious or life-threatening diseases.
http://www.anaphoreinc.com

CalciMedica (USA) is dedicated to the discovery and development of novel small molecule drugs for the treatment of autoimmune and inflammatory diseases. A significant focus of the company's drug discovery strategy is based on the specific inhibition of calcium release-activated calcium (CRAC) channels.
http://www.calcimedica.com/

CoNCERT Pharmaceuticals, Inc (USA) creates new drugs by using precision deuterium chemistry to modify the pharmacology of existing and new small molecule compounds to create a treatment benefit.
http://www.concertpharma.com/

Constellation Pharmaceuticals is the leading biopharmaceutical company dedicated to the development of novel therapeutics in the emerging area of epigenetics, a new field that describes how the selective regulation of chromatin state controls key cellular activities such as gene expression, cell fate decisions, and DNA damage repair.
http://www.constellationpharma.com/

CyDex (USA) develops and commercializes specialty pharmaceutical products based on drug delivery and formulation technologies.
http://www.cydexinc.com/

Genocea Biosciences (USA) - commercializing key breakthroughs in vaccine discovery and development.
http://www.genocea.com/

Locus Pharmaceuticals, Inc. (USA) applies its core fragment-based, computational drug design technology with its capabilities in medicinal chemistry, crystallography and biology to create small molecule product. The company has a portfolio of emerging candidates in development for cancer and inflammation.
http://www.locuspharma.com/

Novalar Pharmaceuticals, Inc.(USA) is a specialty pharmaceutical company.Lead asset NV-101, for the reversal of numbness associated with local dental anesthesia, has completed Phase III trials. An NDA was filed in 2007.
http://www.novalarpharm.com/

NeuroTherapeutics Pharma, Inc., or NTP, is a biopharmaceutical company focused on developing therapies for diseases associated with central nervous system (CNS) hyper-excitability.
http://www.ntprx.com/

Nupathe(USA) - developing innovative therapeutic products for the treatment of neurological and psychiatric disorders where the needs of patients are insufficiently met by current treatments
http://www.nupathe.com/

Rib-X Pharmaceuticals (USA) is developing novel classes of anti-microbials to address unmet needs in resistant community and hospital-acquired infections using structure-based drug design and its proprietary knowledge of the crystal structure of the 50S subunit of the ribosome and other important targets.
http://www.rib-x.com/

Scynexis, Inc. (USA) offers drug discovery and development services to biotech and pharmaceutical companies through a suite of research, development and products.
http://www.scynexis.com/

Synovex(USA) - developing novel antibody therapeutic for rheumatoid arthritis and other indications
Trinity Biosystems (USA) is using its novel platform of oral and nasal delivery to develop proteins and peptide therapeutics.
http://www.trinitybiosystems.com/

Zelos Therapeutics (USA) is developing new treatments for osteoporosis and other indications based on breakthrough discoveries in parathyroid hormone research. Lead candidate Ostabolin C is in Phase II trials.
http://www.zelostherapeutics.com/